More information is available on his Web site, www.drpasswater.com. The reason for this was that Premarin acted like a growth hormone for the uterine lining. New Product Review 2020: AFI, Solgar, Bluebonnet, and More, Immunity Market: How to Communicate and Engage In-Store & Online ​. I then investigated the effect of intake and exposure of phytoestrogens on the risk of breast cancer and on patients who had been diagnosed with breast cancer. Estrone, estradiol and estriol are the three of the most common estrogens. Passwater: Have you found that P. mirifica affects the alpha-estrogen receptor and beta-estrogen receptor differently? She was the first researcher in the world to identify biomarkers of phytoestrogen intake and create a validated database of phytoestrogen content of foods. Pueraria Mirifica can be an effective alternative for synthetic HRT. Ritchie: SERMs are “selective” in that they can block estrogen’s action in breast cells and yet can activate estrogen’s action in other cells, such as bone, liver and uterine cells (see Figure 7). In a study made in 2015, testosterone was administered on rats which led to prostatic hyperplasia. Passwater: Some phytoestrogens are called Selective Estrogen Receptor Modulators? The activated ER enters the nucleus as a homodimer or heterodimer, then binds to a specific DNA sequence, the estrogen response element (ERE), and stimulates estrogen-target gene expression. It is important to extrapolate the results with care, as in animal and human models, complex physiological processes need to be taken into account when considering the effect on humans. Patients with thyroid problems should consult a health care professional if they wish to increase their intake of specific phytoestrogens. These proteins can then influence cell behavior in different ways, depending on the cell type involved. Estrogen mediates these activities via binding to a specific nuclear receptor protein, the estrogen receptor (ER), which is encoded by two genes (ER-α and ER-β) that function as transcription factors to regulate the expression of target genes. Biol. Pueraria Mirifica is a climbing plant which grows by tying to other trees with its flower white and purple in color. My research indicated that this is Professor Margaret Ritchie, Ph.D., of Dundee University and the University of the West of Scotland. (1). I was also completing several research studies at St. Andrews University and the preliminary results indicated that exposure to phytoestrogens may be beneficial to both breast and prostate cancer patients prior to diagnosis. Ritchie: OK, I will provide some background here as this may help explain why different proteins result in different tissues. The estrogen receptors, ER-α and ER-β, oppose and balance one another. Kudzu is an herb used in Chinese medicine to treat alcoholism, heart disease, menopausal symptoms, diabetes, fever, the common cold, and neck or eye pain. Med. But Pueraria Mirifica has been under fire lately due to a few studies showing that some of its compounds may cause cancer, specifically in the breast and uterine areas. She is currently a member of the National Advisers and Inspectors in Science and a member of the editorial board for the Journal of Nutrition and Food Science. You must consult your doctor before acting on any content on this website, especially if you are pregnant, nursing, taking medication or have a medical condition. Genistein binds to a certain estrogen receptor which is called GPER. The term “phytoestrogen” refers to the ability of such compounds to mimic the biological effects of estrogens by binding to and subsequently, activating, the nuclear estrogen receptors. 60 (1), 129–135 (2006). One of the most significant differences between ER-α and ER-β is that ER-α enhances cell division and cell proliferation, a recurring phenomenon in cancer cells. It’s called Pueraria Mirifica and it’s the primary ingredient of Mirifica Science’s. The plant has many amazing benefits that make it one of the most wanted herbs in the cosmetics industry. The use of phytoestrogens, active components found in the herb Pueraria Mirifica, has raised concerns that it may increase the risk for some types of cancers specifically those which are hormone-sensitive. Ritchie: At the time, this was the largest population-based case-control study of diet, inherited susceptibility and prostate cancer in Europe (9, 10). After all, breast enlargemen, Walnuts, Pistachios, Peanuts and Most Other Nuts, decrease the risk of breast cancer in women, Breast Enhancement Products: Pills, Topicals, All Options Reviewed. So, the use of phytoestrogens contained in Pueraria Mirifica may cause cancer in some people. When a chemical activates a gene, it is said to be “upregulated” and it stimulates the production of its protein. ER-β, however, is anti-proliferative (5, 6). Initially, cholesterol is converted to pregnenolone, which is subsequently converted to progesterone. As a result of this personal experience, I decided to use my knowledge of chemistry to try and help in the management of disease, in particular, cancer. If you continue to use this site we will assume that you are happy with it. Kudzu is a vine. My first step was to seek out the world’s best authority in phytoestrogens and cancer. An ideal study would be to link phytoestrogens with a further study involving the immunological response and investigate the combined effect in humans. Gustafsson, “Estrogen Receptor Beta In Breast Cancer—Diagnostic And Therapeutic Implications,” Steroids 74 (8), 635–641 (2009). The most commonly occurring isoflavones in the diet are genistein and daidzein. She was the Royal Society of Chemistry Education Coordinator for Scotland and advisor to the Higher Education Training Council for Ireland. Compounds called isoflavones are thought to be responsible for its potential effects. 98(2), 388–396 (2007). Professor Ritchie’s publication of a validated database of phytoestrogens blazed the way for many other phytoestrogen researchers to follow. As a consequence, exposure to disrupting chemicals may cause considerable damage to a developing fetus. Estrogens are produced from cholesterol. What were your findings? I needed laboratory and clinical evidence as well as the epidemiological evidence presented by Dr. Gordon. The receptors are sites on which estrogens can bind and stimulate a response within the cell. They are receptors, hence their name, that respond to estrogen binding. The effect on humans could be on reproduction, breast development and cancer, prostate cancer and the response of the brain to hormones. The people of Thailand and Burma have been using this herb for a long time and it’s thought to alleviate quite a few health conditions especially for women. Estrogens are responsible for physical changes during puberty in females, which include the start of menstruation and the development of breasts and underarm hair. The medical literature documents the plant's use primarily for menopause, but also for cancer and osteoporosis. Ritchie: My major interest has always been in chemistry and while completing my first degree in pure chemistry at the University of St. Andrews, a close relative suffered from cancer. A.M. Brzozowski, et al., “Molecular Basis Of Agonism And Antagonism In The Oestrogen Receptor,” Nature, 389 (6652), 753-758 (1997). Perhaps I shouldn’t divert you from the main topic, but a study of phytoestrogens on prostate cancer would be extremely important. 2. There is no evidence yet proving that Pueraria Mirifica can increase the risk of cancer in humans. Many scientific researchers found evidence that White Kwao Krua(Pueraria Mirifica) demonstrated clinical efficacy as a female hormone replacement in … The sidebar on p. 54 gives a more detailed explanation for researchers. They were formed about 120 million years ago via the flavone biosynthetic pathway. Over 800 cases and controls completed the study and the results showed a significant reduction in the risk of prostate cancer with increasing serum concentrations of enterolactone (i.e., a phytoestrogen from lignans). A. Morani, M. Warner and J.A. Most of the males and females in this province consume a phytoestrogen herbal substance called Pueraria mirifica PM. As far as I am aware, there is a dearth of studies reporting a negative impact of high phytoestrogen intake (in mothers) on children. It is non-carcinogenic (doesn’t cause cancer), 100% natural and allergies to Pueraria Mirifica are very rare. Unfortu, Enhancing breasts without having to undergo surgery has always been a dream for many women. An Interview with Phytoestrogen Expert, Professor Margaret Ritchie. More information is available on his web site, www.drpasswater.com. Each estrogen receptor has a slightly different structure, depending on the kind of cell in which it is located. We provide important information regarding industry news, research, and trends. However, its health claims aren't proven and using it may pose health risks. It’s also recommended that consumption of soy be made between adolescence and before menopause to get the most benefit. Most women have assumed that “natural” or “bioidentical” HRT is safer than conventional HRT. Although Pueraria mirifica has been used in Thailand for centuries as a rejuvenating adaptogenic herb and to help manage breast cancer, it is mostly unknown in the western world. It’s called Pueraria Mirifica and it’s the primary ingredient of Mirifica Science’s Facial Serum and Bust Serum. Can phytoestrogens and SERMs protect from estrogen mimics? For men, the absence of testosterone or the lack of it can lead to reduced stamina and strength, low sex drive, and thin bones. There was also a significant inverse correlation between the intake of soy foods and the risk of prostate cancer. Some possible side effects are: Nausea; Delayed menstrual cycle, prolonged menstruation In another study, Pueraria Mirifica, Butea Superba, and mucuna collettii were tested for their anti-proliferative actions on MCF-7 or breast cancer cells. There is, however, a study made in March 2012 on animal subjects published in a medical journal called Toxicological Sciences. Ritchie: When estrogen binds to the estrogen receptor in the nucleus of a cell, it affects genes involved in development. 8. They can skip ahead to my next question. As mentioned, phytoestrogens are compounds that mimic the actions of estrogen in the human body. All our products are researched backed and we spend countless hours reading through clinical research to make sure our products do what we say they will. Dr. Ritchie has a background in pure chemistry from the University of St. Andrews and a passion for the role of phytochemicals on health. Pueraria Mirifica extracts genistein and daidzein were given for 30 days. The response will depend on the location of the cell (i.e., in which tissue it is present) (see Figure 5). It account for 16% of all female cancers and 22.9% of invasive cancers in women. In a study made in 2005 in Korea, cancer cell lines from cervical, ovarian, colon, and liver areas were treated with purified phytoestrogens extracted from Pueraria Mirifica. Download it by entering your email below (we will send it to your email), According to lab tests, when GPER is stimulated by genistein, cancer cells seem to proliferate. Pueraria Mirifica is extracted from plants and not made from synthetic ingredients. Products are not intended to diagnose, treat, cure or prevent any disease. The two ERs have unique tissue distributions and their own sets of specific functions. Two effects were reported: first, the growth of the cells over time and during exposure to varying concentrations of Pueraria mirifica. 3. At this point, I decided to find out more about the role of plant chemicals and investigate their properties through research. So, when menstruating women take this herb, they may have increased blood flow. *These statements have not been evaluated by the FDA. Some people can have a negative reaction to pueraria mirifica, especially under certain circumstances. Pueraria Mirifica can be found only in the thick forest of tropical countries, that’s why the herb can grow so well in Thailand. This plant has a tuberous root which can be eaten. How long have you been researching them? Pueraria mirifica and Reducing Cancer Risk. ER-β may also have an important role in the adaptive function of the lung during pregnancy. Ritchie: “Estrogens” refers to a group of hormones with similar chemical structures (see Figure 1) produced in the body from a variety of tissues. J. Med. 11. S0029665109990462. These effects make this herb useful in treating high cholesterol, low libido, hot flashes, osteoporosis, mood swings, and vaginal dryness. /nutrition_library/gordon_2(1).htm. However due to body weight, the same level of exposure to an adult may have no significant effect. To counteract these effects, hormone replacement therapy or HRT is often recommended by doctors. My second step was to visit her laboratory and observe her team of researchers studying P. mirifica’s actions against cancer cells. In the 2007 interviews with Dr. Garry Gordon, he presented epidemiological evidence that P. mirifica lowered the risk of breast cancer. Can Probiotics Make Vaccines More Effective? May I interrupt you? It had been almost 10 years since we discussed the effectiveness and safety of P. mirifica and I wanted to update readers on both the effectiveness and the protection against breast cancer (2, 3). Healthy skin is more than beauty: It indicates your total health, Part 2, WholeFoods Presents ROTY Award to Weavers Way. body is far less than that of Pueraria mirifica. Firstly, Pueraria Mirifica shouldn't be used by women who are pregnant; people clinically determined to have breast cancers, cervical melanoma, cancer of the prostate and cancer of the colon. There is some evidence that endocrine disruptors may affect humans and wildlife. They do however have the power to increase estrogen slightly if taken at very high doses like X per kg of body weight, very high doses and for long periods of time like over a life span. Furthermore, as the beta-estrogen receptor may have anti-proliferative effects and oppose the actions of the alpha-estrogen receptor in reproductive tissue, this may be an important finding on which to base future studies in cancer and breast health. Estrogens are present in both men and women, and they have functions in both, although their levels in women tend to be higher. As of this writing, there are still no long-term Studies involving human subjects on the effects of Pueraria Mirifica in increasing the risk for the cancer types mentioned previously or other types as well. Still, the lab results did on animals merit well-designed and long-term studies that should be made as soon as possible. The can also affect the lungs and heart. In other words, estradiol is the more prominent estrogen in non-pregnant females between puberty and menopause; during pregnancy estriol becomes the more prominent; and after menopause, estrone becomes the primary estrogen. Pueraria mirifica is a plant used in traditional Thai medicine to help balance hormones and bring your body into harmony. As phytoestrogens may be able to bind to the estrogen receptor and potentially prevent the binding or an endocrine disruptor, they may be able to reduce or limit the effects of endocrine disruptors. The information on this website has not been evaluated by the Food & Drug Administration or any other medical body. In other words, the cell does not receive the stimulus from estrogen to grow and multiply (see Figure 6). The research reported that rats exposed to a mixture of two phytoestrogen components most abundant in Pueraria Mirifica may have led to the development of endometrial and mammary cancers. © Copyright 2020 WFC, Inc. All Rights Reserved. As several phytoestrogens have undergone research and been shown to demonstrate SERM-like properties it can be assumed that, based on current research findings, most phytoestrogens may behave in a similar way to SERMs. Overall, the study supported our initial hypothesis that soy foods and enterolactone protect against prostate cancer in older men. Most commercial products containing pueraria are available as rejuvenating, antiaging, or skin-lightening creams or gels, as beauty soaps, or as capsules or tablets for increasing appetite, enlarging breasts, modulating hair growth or regrowth, and other rejuvenating purposes. Estriol is the main estrogen produced during pregnancy. That's why we assume all the risk and guarantee results or you have a 60 days money-back, if our products don't work for you, let us know and we'll refund you, Breast enhancement has always been a lucrative business. The results provided some initial evidence that exposure of breast cancer cells to P. mirifica may increase the ratio of the beta-estrogen receptor relative to the alpha-estrogen receptor over a period of 24 hours and that at higher concentrations, P. mirifica had an anti-proliferative effect on breast cancer cells (11, 12). So even though tampering with the body's hormones is always a risky proposition, that's what the "pueraria mirifica" is claiming to do indirectly, but Instead of providing estrogens to the body – such as herbs and pueraria mirifica – bovine ovary pills cause the body to … Passwater: What are estrogen receptors and how many types are there? These findings indicated the significance of the period of time over which exposure took place and the P. mirifica concentration to which cells were exposed. Last month, we discussed the effectiveness of the herb Pueraria mirifica against menopausal symptoms with Christiane Northrup, M.D. Another effect that was investigated involved the expression of ER-β relative to ER-α. 1. 6. (1). Menopause. Although there are studies made on animals that may show Pueraria Mirifica may increase the risk of uterine or breast cancer because of its phytoestrogenic components, the herb also has anti-tumor, anti-cancer, and anti-proliferative properties. The ovaries, which produce a woman’s eggs, are the main source of estrogens in women. Ritchie: During my visit to Tenovus in Cardiff and my meeting with experts in the field of cancer and phytoestrogens, there was a reference to miroestrol, which along with its “sister” compound, deoxymiroestrol, are the most active phytoestrogens in P. mirifica. Passwater: Okay, let’s start with the basics. It … As a result, the potential properties and actions of phytoestrogens are based on current research and published literature. If so, what is the significance? It’s not so much the estrogen, but the receptor that is most important. Passwater: Whoa! One component of Pueraria Mirifica called spinasterol is showing promising results in its anticancer actions. Interestingly, the period that is most critical during development is the transition from a fertilized egg into a fully formed infant. Isoflavones occur mainly in one subfamily of Leguminosae, namely the Papilionoidae, although they have been reported occasionally in Compositae and Rosaceae. Natl. Passwater: What is the significance of your findings? We do not aim to diagnose, treat, cure or prevent any illness or disease. While based at St. Andrews University I was involved with the largest prostate cancer study in Europe in collaboration with the University of Edinburgh where we investigated the effect of phytoestrogens on the risk of prostate cancer. A fourth estrogen, estetrol, is produced only during pregnancy. Ritchie: As with all nutrient and non-nutrient components of a diet, it is important to follow a lifestyle and dietary regime that is balanced. The study was designed to investigate the effect of phytoestrogen intake and serum concentrations of phytoestrogens on the risk of prostate cancer in men aged 50–74 years. Pueraria Mirifica is considered safe, but there are certain groups of people who should avoid taking it. Making Pueraria Mirifica Safe. This may be useful as some studies have shown that ER-α promotes the growth and proliferation of breast cancer cells. Make sure when taking Pueraria Mirifica that you are not using too much of it at a time. The researches confirm that these chemicals are potent anti-breast cancer, anti-prostate hyperplasia, anti-colon cancer, anti-osteoporosis and also anti-cardiovascular disease via the potent reduction of blood cholesterol and also anti-menopausal syndrome. Ritchie: Currently more than 300 estrogenic compounds have been identified in plants, the most common of which are isoflavones and coumestans. The levels of human sex hormones naturally decrease with aging. Passwater: You and your colleagues were researching the effect of P. mirifica on estrogen receptors while I was visiting your lab in 2008. research to make sure our products do what we say they will. I was very keen to investigate this herb further. Estriol tends to be produced in large quantities during pregnancy, as I mentioned. Passwater: How do estrogen receptors work? So breast cell estrogen receptors are different from bone cell estrogen receptors and both of those estrogen receptors are different from uterine estrogen receptors. Ritchie: Yes, ER-β may promote anti-proliferative effects. Ritchie: Estrogen mimics or endocrine disruptive pollutants may be described as endocrine disruptors. A key person who trained me in phytoestrogen analysis was Dr. Mike Morton. Epidemiologic studies show that the consumption of soy may decrease the risk of breast cancer in women. Furthermore, phytoestrogens have a binding-preference for ER-β and several epidemiological (correlation) studies indicate a breast cancer preventing effect of this class of compounds (8). present in ovarian granulosa cells, kidney, brain, bone, heart, lungs, intestinal mucosa, prostate, and endothelial cells. Pueraria mirifica may be an effective topical therapy for promoting the … Published in WholeFoods Magazine November 2016. Lab studies suggest that kudzu has anti-inflammatory and neuroprotective properties. USA, 93 (12), 5925–5930 (2006). They can also be known as female sex hormones. Passwater: What are estrogens and how do they work? Pueraria Mirifica attaches to estrogen receptors, making more harmful effects of estrogens. It is worth noting that estradiol tends to be present in greater quantities in women of reproductive age. There is no evidence yet proving that Pueraria Mirifica can increase the risk of cancer in humans. Many women have turned to natural forms of hormone replacement for menopause since learning that conventional hormone replacement therapy (HRT) may increase their risks of breast cancer and other health problems. Passwater: What are estrogen mimics or estrogen disruptive pollutants and how do they differ from phytoestrogens and SERMs? 43 (2), 195–200 (2010). Soy is a staple in the diet of Asian cultures, that’s why this anticancer effect was noted particularly in them. Cancer patients are also discouraged from taking this herb. Compound Miroestrol, found in Pueraria Mirifica, inhibits the growth of cancer cells and, therefore, has anti-cancer properties. Dr. Richard Passwater is the author of more than 45 books and 500 articles on nutrition. Dr. Richard Passwater is the author of more than 45 books and 500 articles on nutrition. Kuiper, et al., “Cloning of a Novel Receptor Expressed in Rat Prostate and Ovary,” Proc. 6. Proper safety trials on this plant are lacking. Searing hot flashes, trouble sleeping, vaginal dryness — menopause is a natural yet … In addition, by binding to the estrogen receptor and preventing endogenous estrogen binding (and promoting an estrogenic response), SERMS can block estrogen binding to the binding site and therefore prevent an estrogenic response. As cells begin to grow and differentiate, balancing the effects of hormones and protein changes is very important. Pueraria Mirifica belongs to the most beneficial breast augmentation herbs of all time. 18.2% of all cancer deaths worldwide, including both males and females, are from breast cancer. Herbs such as soy, licorice, red clover, thyme, turmeric, hops, verbena, oregano and damiana are also sources of estrogenic compounds. May Support Vaginal Health. Others claim that Pueraria mirifica can help soften skin, increase breast size, promote weight loss, and prevent heart disease, diabetes, and cancer. Please do. Ritchie: Phytoestrogens are a group of compounds produced naturally by edible plants. Genes provide the blueprints for making proteins in cells. I could post a chart here, but I am trying to "gently" coax anyone whose interest is kindled, to look up Breast Cancer Rates in Thailand compared to the USA. This increase in blood flow can also cause you to become flushed. Another study was made on the two phytoestrogen components but this time they were administered on cancer cell lines from the prostate. To me, that almost seemed to verge on being too good to be true. Different versions of the estrogen response gene have been associated with different risks of developing breast cancer. Ritchie: May I be a little technical for a moment? WholeFoods Magazine is your one-stop resource for health and nutrition articles. I learned that plants contain a huge variety of bioactive compounds (i.e., compounds that can promote an effect on the body or tissue or cell). S. Ramnarine, J. MacCallum, and M. Ritchie, “Phyto-oestrogens: Do They Have A Role In Breast Cancer Therapy?” Proceedings of the Nutrition Society, 68 (OCE2), Jan 2009 , E93 doi: 10.1017/ However, phytoestrogens are toxic to cells. I used one bottle (100 caps) and noticed breast growth. If you take too much Pueraria Mirifica it is dangerous. The result of this study showed that the powdered herb has strong antiproliferative actions in the mentioned gynecological cancer cells. Studies have shown that ER-α is involved in cancer in the uterus and breast, and that the receptor may cause many other negative effects. Rats were exposed to increasing levels of P. mirifica over a period of four weeks and similar effects were noted in the ratio of the beta-estrogen receptor to the alpha-estrogen receptor. Isoflavones constitute the largest proportion of the phenolic antibiotic phytoalexins, compounds that are synthesized only when an infection has started. Dr. Passwater has been WholeFoods Magazine’s science editor and author of this column since 1984. Passwater: Where is your research leading you now? 9. C. Boonchird, T. Mahapanichkul and W. Cherdshewasart, “Differential Binding with ER-alpha and ER-beta of the Phytoestrogen-Rich Plant Pueraria mirifica,” Braz. 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